PITTSBURGH, USA: Many patients with cancer of the oral cavity or oropharynx develop recurrences or new cancers, most often in the first two years after treatment. A new study has now demonstrated that extracts of cruciferous vegetables, such as broccoli, cabbage and garden cress, which have a high concentration of the naturally occurring molecular compound sulforaphane, could help prevent cancer recurrence in survivors of head and neck cancer.
The researchers treated human head and neck cancer cells in the laboratory with varying doses of sulforaphane and a control, and compared them to normal healthy cells that line the throat and mouth. The sulforaphane induced both types of cells to increase their levels of a protein that turns on genes that promote detoxification of carcinogens, like those found in cigarettes, to protect cells from cancer.
In a small preclinical trial, ten healthy volunteers drank or swished fruit juice mixed with broccoli sprout extract for several days. The volunteers had no significant problems tolerating the extract, and the lining of their mouths showed that the same protective genetic pathway activated in the laboratory cell tests was activated in their mouths, indicating that the sulforaphane was absorbed and directed to at-risk tissue.
According to the Centers for Disease Control and Prevention, more than 30,000 new cases of cancer of the oral cavity and pharynx are diagnosed in the U.S. each year and over 8,000 deaths due to oral cancer occur. The five-year survival rate for these cancers is only about 50 percent. Oral cancer mortality rates are nearly twice as high in some minorities, particularly among black males, than among whites.
The study, titled “Prevention of carcinogen-induced oral cancer by sulforaphane,” was published online on June 23 in the Cancer Prevention Research journal ahead of print. It was conducted by researchers at the University of Pittsburgh School of Medicine in collaboration with the Johns Hopkins Bloomberg School of Public Health and the University of California, San Francisco.
By Dental Tribune International
From seeing the spooky forceps and needles to even smelling dental compounds, 5-8% of patients refuse to seek dental care all together and 20% of patients will only go to the dentist when necessary.
I think I have odontophobia. What can I do to prevent panic during visits?
Easier said than done - practice positive self-talk! Tell yourself “YOU CAN DO IT!”
Make sure to remind yourself “everything WILL be okay.” Your dentist is a professional and is someone you can trust.
Don’t be nervous - speak up to your dentist. Let him/her know when you’re having a rough time. Listening to your concerns face-to-face helps both sides - you and your dentist. Your dentist can help make an ideal and reasonable commitment that makes you feel comfortable because dental health is SO important! Knowledge is power!
Download your favorite podcast, album, or playlist before heading to the office. Distract your thoughts and link the experience to something you ENJOY.
Don’t forget headphones! Your dentist will not be upset if you put your headphones in to distract your thoughts.
Take deep breaths! Think about pleasant experiences in your life to stay calm.
Here at Fabulous Smiles, we have a therapy dog named Bailey that will ease any panic you might have.
You never outgrow your smile!
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