PITTSBURGH, USA: Many patients with cancer of the oral cavity or oropharynx develop recurrences or new cancers, most often in the first two years after treatment. A new study has now demonstrated that extracts of cruciferous vegetables, such as broccoli, cabbage and garden cress, which have a high concentration of the naturally occurring molecular compound sulforaphane, could help prevent cancer recurrence in survivors of head and neck cancer.
The researchers treated human head and neck cancer cells in the laboratory with varying doses of sulforaphane and a control, and compared them to normal healthy cells that line the throat and mouth. The sulforaphane induced both types of cells to increase their levels of a protein that turns on genes that promote detoxification of carcinogens, like those found in cigarettes, to protect cells from cancer.
In a small preclinical trial, ten healthy volunteers drank or swished fruit juice mixed with broccoli sprout extract for several days. The volunteers had no significant problems tolerating the extract, and the lining of their mouths showed that the same protective genetic pathway activated in the laboratory cell tests was activated in their mouths, indicating that the sulforaphane was absorbed and directed to at-risk tissue.
According to the Centers for Disease Control and Prevention, more than 30,000 new cases of cancer of the oral cavity and pharynx are diagnosed in the U.S. each year and over 8,000 deaths due to oral cancer occur. The five-year survival rate for these cancers is only about 50 percent. Oral cancer mortality rates are nearly twice as high in some minorities, particularly among black males, than among whites.
The study, titled “Prevention of carcinogen-induced oral cancer by sulforaphane,” was published online on June 23 in the Cancer Prevention Research journal ahead of print. It was conducted by researchers at the University of Pittsburgh School of Medicine in collaboration with the Johns Hopkins Bloomberg School of Public Health and the University of California, San Francisco.
By Dental Tribune International
1. Brush Your Mouth OftenNot just your teeth, you should brush everything in your mouth. Your gums, your tongue, the roof of your mouth. All of these things need to be brushed and brushed often. This will help keep your teeth cleaner longer and prevent germs from taking root.
2. Floss OftenAs most dentists will tell you, flossing is a good thing to do to keep your teeth clean. Brushing can clean the surfaces, but can't do much for the spaces in between. You need to floss to get a totally clean, and you should floss at least once a day.
3. Eat A Teeth-Friendly DietMost people indulge in sugary foods because they taste good. However, sometimes the best tasting foods can be the most harmful to your teeth. Things like sodas, candies, and other sugary items should be consumed in moderation.
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